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KMID : 0350519950480020407
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Journal of Catholic Medical College
1995 Volume.48 No. 2 p.407 ~ p.417
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Genetic Frequencies of Aldehyde Dehydrogenase 2 in the Patients with Alcohol Dependence
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Abstract
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Mitochondrial aldehyde dehydrogenase(ALDH2) is one of genetically determined isoenzymes which is the most responsible for the oxidative metabolism of alcohol. Individual difference in catalytic activity of aldehyde dehydrogenase results in
varying
concentration of acetaldehyde during ethanol metabolism. Inactive enzyme ALDH2 encoded by mutant allele ALDH＊2 gives rise to'higher concentration of acetaldehyde than active ALDH2 encoded by normal allele ALDH2＊1 does. Unpleasant symptoms
induced
with
acetaldehyde accumulation may affect the alcohol consumption behavior. Polymorphism of ALDH2, thus, can possibly be a genetic factor of alcohol dependence.
Therefore, this study was designed to investigate the association of ALDH2 genetic types with the risk and clinical variables of alcohol dependence. Genetic types of normal homozygous ALDH2＊1/1), mutant homozygous ALDH2＊2/2 and heterozygous
ALDH2＊1/2
were typed with the use of dotblot hybridization method and restriction fragment length polymorphism method in 43 patients with alcohol dependence and 27 normal controls. The frequencies of ALDH2 genetic types were compared between patient group
and
control group. Among the patients, the frequencies of ALDH2 genetic types were compared in terms of Cloninger's types and in terms of family history of alcoholism. The age of first drink, age of onset of alcohol dependence, and the time span from
first
drink to onset were compared respectively between the patients with ALDH2＊1/1 and the patients with ALDH2＊1/2.
@ES The results were as follows :
@EN 1. Frequencies of the subjects with ALDH2＊1/1 were significantly higher and those with ALDH2＊1/2 and ALDH2＊2/2 were significantly lower in patient group than in control group.
2. The frequency of the subjects with ALDH2＊1/1 and those with ALDH2＊1/2 did not related to family history of patients.
3. There was no significant difference for the age of first drink between the patient group with ALDH2＊1/1 type and that with ALDH2＊1/2 type
4. The onset age of alcohol dependence was significantly was significantly earlier in the patient group with ALDH2＊1/1 type than in that with ALDH2＊1/2 type.
5. The time span from first drink to onset tended to be shorter in the patient group with ALDH2＊1/1 type than in that with ALDH2＊1/2 type.
6. No significant differences for the frequencies of ALDH2＊1/1 and ALDH2＊1/2 were observed among Cloninger's type groups.
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KEYWORD
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